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The most common disease of GH surplus is a pituitary gland consisting of somatotropic cells in the front pituitary gland. These somatotropic adenomas are benign and grow slowly and gradually produce more and more GH. For years, the main clinical problems are GH gains. Finally, the adenoma may become large enough to cause a headache, weaken vision by pressure on optic nerve or cause lack of other pituitary hormones by displacement.

Prolonged GH excess consumes legs, fingers, and toes on the leg. Included problems include sweating, nerve pressure (eg carpal tunnel syndrome), muscle weakness, excess hormone binding globulin (SHBG), insulin resistance or even a rare type of type 2 diabetes and impaired sexual function.

GH secreting tumors are typically recognized during the fifth decade of life. It is extremely rare for such a tumor to occur during childhood, but when it happens, excessive GH can cause excessive growth, commonly referred to as pituitary gigantism. Surgical removal is the usual treatment for GH-producing tumors.

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